Joseph H.A. Vissers

RNAsum integrates WGS and WTS data to improve cancer diagnostics by corroborating clinically relevant variants and supporting therapeutic decisions.

This study identifies resistance mechanisms to TEAD inhibitors by showing MAPK hyperactivation can counteract their effects and suggests combining TEAD and MEK inhibition as a therapeutic strategy.

The paper identifies how JNK and Hippo pathways regulate epithelial integrity by controlling an overlapping transcriptome, preventing tumour initiation through shared gene repression.

The paper identifies a PP2A-Integrator complex that opposes CDK9 activity to regulate transcription and shows its therapeutic synergy in leukemia.

This study identifies Pits and CtBP as Tgi-interacting proteins that cooperate in transcriptional repression of Hippo pathway target genes in Drosophila, with conservation in human orthologs.