James R. Edgar

This study identifies tetherin homodimerisation as essential for exosome tethering, showing that mutations affecting tetherin trafficking to ILVs have minimal impact on exosome retention.

This paper identifies 2B* as an EMCV protein that antagonizes innate immune signaling by interacting with 14-3-3 proteins, specifically through the RRNSS sequence.

This study shows that tetherin retains MT1-MMP-containing exosomes at breast cancer cell surfaces, enhancing ECM degradation and invasion.

This study shows that VPS34 deficiency in regulatory T cells causes a fatal lymphoproliferative disorder by impairing metabolic and functional processes, despite normal development and in vitro suppression.

The paper uses a multiomic approach to study Retromer's role in lysosomal health in human neuroglioma cells, revealing proteomic and transcriptomic changes linked to neurodegeneration.