Carla J. Weinheimer

This study shows that FAP-targeted BiTE(R) molecules, intended to reduce cardiac fibrosis, instead worsen heart function by triggering harmful immune responses.

The paper maps monocyte differentiation trajectories in the infarcted heart using genetic lineage tracing and single-cell RNA-sequencing, identifying a protective IFN-responsive macrophage subset.

This study identifies RUNX1 as a key regulator of cardiac recovery by reprogramming macrophages, showing that its inhibition promotes heart function recovery in a chronic heart failure model.

This study shows that phosphorylation of CRYAB leads to condensate formation and worsens heart failure after myocardial infarction.

This study shows that a ketogenic diet improves heart failure in mice without requiring increased cardiac ketone metabolism.