Shayna L. Showalter

This paper introduces stochprofIC, an algorithm for noise-corrected state variability inference in single cells, validated using mini-bulk data from mouse brains and human breast cancers.

OrganoSeg2 improves organoid segmentation and tracking, outperforming alternatives and enabling analysis of growth and radiotherapy responses in breast cancer organoids.

This study develops zero-passage organoids from luminal breast cancer patient samples to test genetic and pharmacologic perturbations, finding variable hormone responsiveness and complex interactions with sulforaphane and NQO1 knockout.