Kevin A. Janes

This paper introduces stochprofIC, an algorithm for noise-corrected state variability inference in single cells, validated using mini-bulk data from mouse brains and human breast cancers.

The paper shows coreceptors inhibit TGFβ signaling more often than they promote it, altering ligand perception through competition in multi-ligand systems.

This study identifies cell competition as a key driver of gliomagenesis by showing that pre-malignant OPCs outcompete wildtype cells, and inhibiting this process reduces tumor growth.

The paper identifies topoisomerase I (Top1) depletion in aging yeast cells and shows its impact on rDNA silencing and replicative lifespan.

The paper investigates the effect of a PCSK5M452I mutation in MCF10DCIS.com cells, finding it hypomorphic and not responsible for the cell line's characteristics.

OrganoSeg2 improves organoid segmentation and tracking, outperforming alternatives and enabling analysis of growth and radiotherapy responses in breast cancer organoids.

The paper develops and applies Cahn-Hilliard solvers to model biomolecular condensate dynamics, showing they match experimental behaviors of chromosomal passenger complex condensation.

This study shows that inhibiting acid ceramidase (AC) enhances venetoclax's effectiveness in venetoclax-resistant AML by inducing a cytotoxic integrated stress response.

This study develops zero-passage organoids from luminal breast cancer patient samples to test genetic and pharmacologic perturbations, finding variable hormone responsiveness and complex interactions with sulforaphane and NQO1 knockout.

The paper identifies three host transcriptome adaptions in heart infections by cardio-pathogenic viruses, which are independent of the virus and reversible through pathway perturbation.

The paper estimates protein copy numbers from mRNA data across 369 cell lines and applies it to reclassify breast cancer subtypes and predict viral receptor abundances.

This study identifies two sphingolipidomic subtypes in AML, with one subtype associated with poor clinical outcomes and high-risk features.

The paper identifies how HER2 nucleocytoplasmic transport dynamics drive escape from DCIS-like state through systems-level feedback mechanisms.

The paper shows JNK and Erk signaling pathways have distinct roles in initiating and maintaining cell senescence after DNA damage through AP-1 and the senescence-associated secretory phenotype.

The paper identifies distinct structural domains in the MUNC lncRNA that regulate different promyogenic genes through cis and trans mechanisms.

The paper models the complete kinetics of coxsackievirus B3 to identify human determinants of host-cell feedback, revealing that MAVS cleavability influences viral outcomes.

The paper introduces nested resampling strategies to improve the interpretation of in vivo regression models by preserving the tissue-animal hierarchy and assessing latent variable stability.

The paper introduces an ultrasensitive fiveplex assay to measure multiple kinase activities simultaneously, demonstrating its application in studying viral infection.

This paper introduces 10cRNA-seq, an in situ method for sequencing 10 microdissected cells, showing improved sensitivity and reliability compared to scRNA-seq.