Hui Zong

This study shows that microenvironment T-type calcium channels promote glioblastoma growth by regulating neuronal and glial processes, and that blocking these channels with mibefradil enhances the effectiveness of standard therapies.

This study identifies cell competition as a key driver of gliomagenesis by showing that pre-malignant OPCs outcompete wildtype cells, and inhibiting this process reduces tumor growth.

This study identifies age-associated delays in immune resolution to respiratory viral infection by analyzing single-cell RNA sequencing and flow cytometry data from young and aged mice.

The paper identifies metabolic state vulnerabilities in cancer cell lines and discovers synthetically lethal associations between metabolism, mutations, and therapeutic targets.

This paper introduces 10cRNA-seq, an in situ method for sequencing 10 microdissected cells, showing improved sensitivity and reliability compared to scRNA-seq.