Robert Eldon Brown

The paper identifies high MYC activity as a targetable feature in lung adenocarcinoma using phenotype-based subtyping and shows sensitivity to a dual inhibitor of MYC co-factors.

This study identifies G-quadruplex structures as regulators of long-range transcriptional reprogramming in drug-resistant ovarian cancer, showing their role in promoting resistance and potential as therapeutic targets.

This study shows that inhibiting H3K27/H3K9 methylation maintenance reverses cMYC-mediated immune repression in cancer, improving survival in mouse models.

The paper predicts cancer cell-of-origin from DNA sequences by matching mutational landscapes to chromatin modification patterns in normal tissues.

The paper investigates the prognostic significance of ESRRA and TGFBR3 co-expression in serous ovarian cancer using TCGA data, but finds no validation in additional datasets.