Author

Isabel CA Dye

Imperial College LondonORCID 0009-0001-0877-5025Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Daniel J. MurphyiD· 2 shared Iain A. McNeishiD· 2 shared Matthew John FuchteriD· 2 shared Nicola BradyiD· 2 shared Robert Eldon BrowniD· 2 shared Sarah LaingiD· 2 shared Catherine FickeniD· 1 shared Claire Kennedy DietrichiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Daniel J. MurphyORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintMay 1, 2026

Phenotype-dependent subtyping exposes high MYC activity as a targetable dependency in LuAd

Sarah Laing, Isabel Dye, Ryan M. Byrne…·Daniel J. Murphy

The paper identifies high MYC activity as a targetable feature in lung adenocarcinoma using phenotype-based subtyping and shows sensitivity to a dual inhibitor of MYC co-factors.

DOI 10.64898/2026.04.27.721038

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintOct 18, 2023

cMYC-mediated immune repression is reversed by inhibition of H3K9/H3K27 methylation maintenance

Isabel CA Dye, Sarah Laing, Ian Garner…·Robert Eldon Brown

This study shows that inhibiting H3K27/H3K9 methylation maintenance reverses cMYC-mediated immune repression in cancer, improving survival in mouse models.

DOI 10.1101/2023.10.18.562888

mousehuman

𝕏 PostBluesky