Sarah Laing

The paper identifies high MYC activity as a targetable feature in lung adenocarcinoma using phenotype-based subtyping and shows sensitivity to a dual inhibitor of MYC co-factors.

The paper identifies that CD27+ γδ T cells impair the differentiation of tumor-associated macrophages into airway macrophages in lung adenocarcinoma.

This study shows that inhibiting H3K27/H3K9 methylation maintenance reverses cMYC-mediated immune repression in cancer, improving survival in mouse models.

The paper optimizes sample preparation from primary mouse tissue to maintain RNA integrity for translatome analysis techniques like polysome and ribosome profiling.

The paper investigates how ERBB signaling contributes to immune evasion in KRAS-driven lung adenocarcinoma using a novel mouse model and finds that transient ERBB blockade can restore immune surveillance when combined with PD1 blockade.