Karl Matter

This study shows ZONAB regulates endothelial cell senescence by controlling DNA methylation and mitochondrial function, impacting angiogenesis and vascular health.

This study identifies Arhgef18 as a critical component of the retinal outer limiting membrane, showing its role in maintaining retinal homeostasis and preventing degeneration.

This study identifies KALRN and TMCO1 as interdependent regulators of trabecular meshwork homeostasis and intraocular pressure, linking ER and calcium homeostasis to glaucoma pathogenesis.

The paper designs a stapled peptide stP5 that inhibits GEF-H1-RhoA signaling in inflammation, showing 100-fold higher activity than the unstapled P5 peptide.

This study shows ZO-1 regulates YAP activity and cell proliferation through a mechanosensitive network involving GEF-H1 and TBK1, independent of Hippo signaling.