Chihiro Emori

The paper uses single-cell and bulk RNA sequencing to study DNA damage response in mouse ovaries, identifying novel genes and pathways specific to oocytes.

This study shows that FBXO24 deletion in mice leads to abnormal RNP granule accumulation in sperm flagella, causing infertility due to impaired flagellar structure and sperm motility.

This study shows that age-related structural changes in the zona pellucida reduce fertilization rates in mice by impairing cumulus-oocyte interactions and sperm binding.

This study shows that inhibiting CHEK2 protects primordial oocytes from chemotherapy-induced damage, suggesting it could be used to preserve ovarian function in cancer patients.

This study investigates how cleavage of ZP2 in the egg zona pellucida leads to oligomerization and structural changes that block polyspermy.

This study shows that DCST1 and DCST2 are essential for sperm-egg fusion in mice and zebrafish, with mutations leading to male infertility.

The paper shows that sex-specific modifiers, like CHK2, allow female fertility without PRDM9, revealing sex-specific regulation of meiotic recombination.