Parveen Kumar

This study identifies immunosuppressive mechanisms in osteosarcoma using single-cell and spatial transcriptomics, revealing interactions between MDSCs, T-cells, and tumor cells that promote an immunosuppressive microenvironment.

The paper uses single-cell and bulk RNA sequencing to study DNA damage response in mouse ovaries, identifying novel genes and pathways specific to oocytes.

The paper shows that PV-INs have unique metabolic specializations lost after TBI, which can be rescued by 2-deoxyglucose, and identifies PGC-1α and lncRNAs as key factors in this dysfunction.

The paper identifies driver genes for type 2 diabetes using causal network perturbation analysis and single-cell RNA sequencing in mouse models.

The paper develops a tool to guide scRNA-seq experimental design and analysis for cell type identification, showing that Seurat or Simlr work well with high marker gene fold changes.