Ross A. Marklein

This study evaluates how different isolation and storage methods affect neural extracellular vesicles' properties and immunomodulatory activity.

This study develops a high-throughput morphological assay to evaluate how MSC-EVs modulate brain pericyte secretory phenotype, showing distinct morphological responses under different manufacturing conditions.

This paper demonstrates that MSC-EVs modulate microglia morphology and cytokine secretion, suggesting their therapeutic potential for neuroinflammation, and introduces a high-throughput morphological screening method for EV bioactivity.

The paper screens MSC morphology in response to inflammatory priming to identify optimal conditions for EV production and microglia modulation in bioreactors.