Nitin Phadnis

The paper establishes hybrid Drosophila cell lines to study genome instabilities and identifies incompatibility genes and chromosomal regions prone to loss in hybrids.

This study maps dicentric chromosome breakage hotspots in Drosophila and identifies structural complexity, replication-transcription conflict, and transposon involvement as key factors.

The paper introduces CheC-PLS, a proximity-labeling technique that uses Nanopore sequencing to decode chromosome organization by identifying methylated bases along long reads, demonstrating its application in budding yeast.

The paper identifies a 2:1 male offspring ratio in a human family, suggesting potential segregation distortion caused by a distorting Y-chromosome.

The paper reconstructs the evolutionary history of the Drosophila pseudoobscura Sex-Ratio chromosome, showing it has undergone cycles of drive, suppression, and escape from suppression, with current lack of suppression being a transient state.

The paper shows that a meiotic driver in Drosophila pseudoobscura causes hybrid male sterility when moved between subspecies.

The paper identifies Overdrive as a gene essential for targeted sperm elimination in the Segregation Distorter system in Drosophila.

The paper detects recurrent positive selection in mammalian genomes across multiple clades, finding shared selective pressures and highlighting PIGR as a gene involved in a long-term molecular arms race.

The paper identifies two specific loci responsible for hybrid incompatibility between D. melanogaster and D. sechellia using a triple-hybrid cross and whole genome sequencing.

The paper analyzes the evolutionary dynamics of a segregation distorter in Drosophila pseudoobscura, finding that it persists due to suppressed recombination and epistatic selection.

The paper investigates the chromatin localization differences of hybrid lethality proteins in Drosophila species and identifies altered protein interactions between gfzf and HMR in hybrids.