Mirjam C. van der Net

This study shows that mechanical strain on intestinal organoids reduces the maturity of absorptive lineage cells by expanding early-stage enterocytes and downregulating maturation programs.

This study shows cancer cells follow intrinsic self-organized programs that coordinate tumor cell state transitions during growth, revealing mechanical gradients and stereotyped patterns of heterogeneity and plasticity.

This study shows that mechanical signals from the Collagen I-rich matrix drive fate transitions in colorectal cancer cells, enabling metastasis despite lacking Lgr5 expression.

This study shows mechanical strain activates EGFR-ERK signaling in epithelial cells via E-cadherin-induced ADAM17-mediated ligand shedding.