Gary C. T. Chan

This study shows HCMV activates HSF1 in monocytes to promote survival via mTORC1-mediated translation of pro-survival transcripts.

This paper shows HCMV extends monocyte lifespan by blocking apoptosis and triggering necroptosis, which it suppresses by sequestering MLKL in the nucleus.

This study uses scRNA-seq to compare transcriptomic responses of DENV-infected and bystander macrophages under ADE and conventional infection, revealing distinct gene expression patterns and pathways.

This study shows that DENV infection enhances B cells via their BCR, linking ADE potential to B cell susceptibility and highlighting B cells as a key reservoir in immune-mediated DENV enhancement.

Inhibiting HSF1 reduces HCMV replication in vitro and in vivo by targeting an early stage of the viral replication cycle.

This study shows virion-associated US28 modulates Akt activity to suppress HCMV lytic replication in monocytes, enabling quiescent infection.