Christine M. O’Connor

This study shows that platelet PAR4 signaling, interacting with estrogen receptor beta, drives glioblastoma progression and immune suppression, with sex-specific effects on survival and TME dynamics.

This study shows that deletion of UL33 from HCMV genome reduces lytic replication in epithelial cells by impairing Gq-dependent signaling and gene expression.

This paper identifies the activation of the BTK-DDX41-STING signaling pathway during CMV lytic infection and shows how the virus subverts this pathway by reducing DDX41 activity.

This study identifies UL78 as a viral factor that facilitates the switch from latency to reactivation in CMV-infected myeloid cells by modulating cellular signaling.

This study shows that inhibiting MAPK signaling suppresses CMV reactivation in CD34+ Kasumi-3 cells, suggesting a therapeutic target for preventing viral reactivation in immunocompromised patients.

Inhibiting HSF1 reduces HCMV replication in vitro and in vivo by targeting an early stage of the viral replication cycle.

This study shows virion-associated US28 modulates Akt activity to suppress HCMV lytic replication in monocytes, enabling quiescent infection.

This study shows CTCF binding to the HCMV MIE locus maintains latency by enabling chromatin looping that represses transcription, which is lost during reactivation.

This study shows that PALA enhances antiviral responses by activating non-canonical NOD2 signaling, improving type I interferon production and ISG expression.