Donna L. Färber

The paper presents the Human Gut Cell Atlas v1.0, a unified reference of gut cell diversity, revealing how tissue structure influences cellular composition and enabling disease and organoid analysis.

This study identifies how obesity alters the pancreatic immune landscape by shifting macrophage subsets and enhancing T-cell interactions, contributing to chronic inflammation.

The paper analyzes tissue-resident immune responses in vaccinated individuals to show that antibody responses are driven by lymphoid tissue B and CD4 T cells, not blood.

The paper shows that NK cell responses to CMV infection differ between infants and adults, influenced by age and T cell immunity, with infant NK cells exhibiting adaptive-like features and tissue seeding.

This study shows APOL3 links lysosomal damage to mitochondrial DNA release and type I IFN production via BAK/BAX pores and cGAS/STING signaling.

This study identifies tissue-specific transcriptional and protein profiles of human macrophages in various organs during homeostasis and activation, showing homology to mouse macrophages and responsiveness to cytokine stimuli.

The paper profiles immune cell RNA and protein expression across tissues and age to identify tissue-specific and age-related immune signatures.

The paper develops a variational deep-learning method to model memory T cell dynamics in mice, revealing phenotypic diversity and long-term heterogeneity in lung-resident TRM cells.

This study compares transcriptional profiles of memory T cells in infants and adults to identify age-specific regulatory mechanisms.

This paper introduces MMoCHi, a multimodal classifier for CITE-seq data that improves immune cell subset annotation by integrating transcriptomic and proteomic data.

The paper introduces the Immune Signatures Data Resource, a compendium of standardized systems vaccinology datasets for comparative vaccine response analysis.

The paper identifies molecular and structural changes in aging human lungs that contribute to fibrosis and impair lung function.