Christiaan Hendrik van Dorp

The paper analyzes tissue-resident immune responses in vaccinated individuals to show that antibody responses are driven by lymphoid tissue B and CD4 T cells, not blood.

The paper develops a variational deep-learning method to model memory T cell dynamics in mice, revealing phenotypic diversity and long-term heterogeneity in lung-resident TRM cells.

The paper quantifies self-renewal and replacement rates of CD4+ TRM in skin and gut LP using fate mapping and models, finding site-specific differences in residency and turnover.

This study shows that memory CD4+ T cell persistence depends on cell age, not host chronological age, using mouse models and mathematical models.