Takuya Mabuchi

This study identifies the N-terminal intrinsically disordered region of RolA as critical for self-catalytic interfacial nucleation during rodlet formation.

This study shows zinc finger domains bind low-complexity domain polymers in a cross-β-dependent manner, suppressing polymer formation and preferentially recognizing polymeric LC domains.

This study identifies Kapβ2 as a target of DPRs, showing how DPR binding alters its phase-modifying function, leading to toxic RBP condensates in ALS models.