Masaaki Sugiyama

HA10, a humanized anti-ADAMTS13 antibody, preserves residual ADAMTS13 activity to prevent cardiovascular bleeding without causing thrombosis in non-human primate models.

The paper uses high-speed AFM and biophysical methods to study dynamic conformational changes in multidomain glycosyltransferases, revealing diverse organizational strategies.

The paper quantifies the kinetic hierarchy of Kai protein complex formation in cyanobacteria, revealing distinct assembly dynamics that regulate the circadian oscillator.

The paper develops a protocol combining segmental deuteration and multi-step protein ligation with SAXS and iCM-SANS to improve discrimination of conformational ensembles in multi-domain proteins.

This study shows zinc finger domains bind low-complexity domain polymers in a cross-β-dependent manner, suppressing polymer formation and preferentially recognizing polymeric LC domains.

This study identifies Kapβ2 as a target of DPRs, showing how DPR binding alters its phase-modifying function, leading to toxic RBP condensates in ALS models.

This study establishes a mechanistic model of amyloid oligomer and protofibril formation in bovine insulin using light scattering and kinetic analysis, revealing end-to-end association as the rate-limiting step.