Nicolas Jullien

The paper shows spectrin condensates facilitate the formation of the periodic axonal structure by acting as local assembly hubs that later develop into a stable lattice.

The paper identifies non-synaptic exocytosis along axon shafts and shows how the submembrane actin-spectrin skeleton regulates this process.

This study shows that specific mutations in the C-terminal domains of MT5-MMP reduce C99 and Aβ levels, suggesting a potential therapeutic strategy for Alzheimer's disease.

This study uses CRISPR/Cas9-edited human pituitary organoids to show that NFKB2 mutations impair corticotroph differentiation, confirming its role in ACTHD.

The paper investigates how the actin-spectrin scaffold in axons regulates clathrin-mediated endocytosis, finding that spectrin clearings restrict pit formation and endocytic activity.

This study identifies MT5-MMP's role in regulating APP processing and Aβ levels through proteolytic and non-proteolytic mechanisms in Alzheimer's disease.