Grant Kinsler

The paper shows that fitness variation across drug environments in yeast is organized by a low-dimensional phenotypic structure, revealing modular phenotypic modules that constrain adaptive mutations.

The paper shows that viral resistance in human skin cells is inherited through cellular lineages and preserved across generations.

The paper uses yeast mutants to show that fitness can be predicted by low-dimensional genotype-phenotype-fitness maps across environments, supporting a limiting functions model of fitness.

SpaceBar enables clone tracing and spatial transcriptomics profiling by using synthetic barcodes to label cells and analyze gene expression in situ.

The paper develops a computational method to correct barcode processing biases in bulk fitness assays, improving fitness estimates in yeast variant libraries.

This study shows that early adaptive mutations in yeast are pleiotropic, while later mutations are modular, focusing on respiration over fermentation.

The paper identifies distinct fitness tradeoff groups among fluconazole-resistant yeast mutants, suggesting different resistance mechanisms and implications for multidrug therapy design.