Gavin J. Sherlock

The paper describes updates to the Candida Genome Database, including a new interface and tools for improved data access and analysis.

The paper shows that the K5 capsular polysaccharide of E. coli Nissle 1917 sensitizes it to thioridazine and related antipsychotics, revealing CPS as a vulnerability under non-antibiotic drug pressure.

This paper introduces SCRIVENER, a bacterial mating-based DNA assembly platform that enables high-throughput, low-error DNA construction of up to 23 kb constructs.

This study experimentally evolves yeast to show that mutations beneficial in early stationary phase are detrimental in late stationary phase, indicating a fitness trade-off.

The paper investigates how new centromeres evolve and become fixed in budding yeast by analyzing 138 species and 2,500 isolates, showing that kinetochore interface constraints influence centromere evolution.

This study characterizes the crAssphage lifestyle as a phage-plasmid, demonstrating its persistence in the gut microbiome without causing host lysis or chromosomal integration.

The paper describes updates to the Candida Genome Database, focusing on annotation, visualization, and integration of clinical data for research on Candida species.

Saccharomyces Genome Database released two S288C annotation updates (R64.4.1, R64.5.1) adding ncRNAs, ORFs and uORFs, overhauled YeastPathways, and expanded search, GFF and web features.

The paper shows that spindle architecture limits karyotype evolution in budding yeast by demonstrating that chromosome fusions are tolerated until a critical centromere number is reached.

This study shows that early adaptive mutations in yeast are pleiotropic, while later mutations are modular, focusing on respiration over fermentation.

This paper introduces an in vivo plasmid barcoding method for high-throughput sequence verification and demultiplexing of pooled libraries, demonstrating high accuracy and cost-effectiveness.

The paper updates the Alliance of Genome Resources' central infrastructure, adding tools and enhancing data management and curation capabilities.

The paper reanalyzes data from Shen et al. to argue that most synonymous mutations in yeast genes are not deleterious, challenging their original conclusions about fitness effects.

This study shows that S. cerevisiae cells can survive without Pds5 if Mcd1 levels are increased and SUMO-PCNA is elevated, revealing Pds5's role in cohesin stability and DNA replication coordination.