Arnaud Petit

This paper models ex vivo drug response in pediatric AML by decomposing drug molecules into structured features and using graph-based methods to identify key molecular predictors of cellular viability.

The paper identifies a chemoresistant leukemic stem cell population in T-ALL with high CD44 expression and enhanced E-selectin binding, associated with poor prognosis and relapse.

This study identifies an inflammatory microenvironment in T-ALL that supports progression, with HGF as a potential therapeutic target.

The paper identifies co-regulated genes in leukemia using CRISPRi screening of super-enhancer regions, showing that combined inhibition of KIT and PDGFRA synergizes to impair leukemia cell growth.