Juan Pablo Robles

This study identifies integrin α5β1 as the receptor for vasoinhibin's HGR motif, revealing its role in inhibiting angiogenesis and vascular permeability through integrin activation.

This study evaluates VIAN-c4551 eye drops for treating diabetic macular edema, showing they reach therapeutic concentrations in the retina and reduce vascular leakage.

This study shows that VIAN-c4551 reduces lung melanoma metastasis in mice by inhibiting vascular permeability and melanoma cell extravasation.

This study identifies renin as a protease that cleaves prolactin to generate vasoinhibin, a RAS-mediated regulator of blood vessel growth and function.

This study identifies that the apoptotic, inflammatory, and fibrinolytic actions of vasoinhibin are mediated by a distinct motif from its antiangiogenic HGR motif.