Author
University of PennsylvaniaORCID 0000-0001-8863-1859Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
JiaBei Lin, Jaskamaljot Kaur Banwait, Ayush Saurabh…·James Shorter
This study reveals that Hsp104, an AAA+ ATPase, functions as a bidirectional, processive translocase by switching direction through biased stochastic conformational transitions.
Lin Guo, Jacob R. Mann, Jocelyn C. Mauna…·James Shorter
The paper identifies short RNAs that prevent and reverse pathological fibrillization of RNA-binding proteins like FUS and TDP-43, showing therapeutic potential for ALS/FTD.
JiaBei Lin, Peter J. Carman, Craig W. Gambogi…·James Shorter
This paper identifies design principles for modifying Hsp104 to enhance its therapeutic potential by tuning its collaboration with Hsp70 and Hsp40.