Author

Daniel M. Williams

Horizon Discovery (United Kingdom)ORCID 0000-0001-8483-021XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:comparative / phylogenetic analysis· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:multiple species· 1

Frequent Co-Authors

Andrew A. PedeniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

2 papers

Recent·Most cited

ImmunologybioRxivPreprintSep 1, 2026

An in silico analysis reveals eutherian NLRP3 is distinguished by conserved regulatory features absent in non-eutherian NLRP3-like proteins

Daniel M. Williams

The paper analyzes NLRP3 evolution and finds eutherian NLRP3 has unique regulatory features absent in non-eutherian NLRP3-like proteins.

DOI 10.64898/2026.04.26.720791

multiple speciesprotein sequence

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Cell BiologyeLifePeer-reviewedMar 26, 2024

S-acylation of NLRP3 provides a nigericin sensitive gating mechanism that controls access to the Golgi

Daniel M. Williams, Andrew A. Peden

This study shows that S-acylation of NLRP3's Cys-130 residue regulates its Golgi association through a nigericin-sensitive cycle, linking Golgi dysfunction to NLRP3 activation.

30 citations

humanproteomics

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