Andrew A. Peden

This study shows that S-acylation of NLRP3's Cys-130 residue regulates its Golgi association through a nigericin-sensitive cycle, linking Golgi dysfunction to NLRP3 activation.

The paper identifies reduced EXOSC2 expression as protective against SARS-CoV-2 infection and clinical COVID-19 by inhibiting viral replication and upregulating antiviral genes.

The paper shows that Acat1 gene knockout improves cholesterol levels and extends lifespan in mutant Npc1 mice by correcting cholesterol mislocalization.