NeurosciencebioRxivPreprint
PI31 expression prevents neuronal degeneration in a mouse Parkinson Disease model
This study shows that PI31 expression in a mouse Parkinson's Disease model prevents neuronal degeneration and extends lifespan.
1 citation
Author
Adi Minis
Rockefeller UniversityORCID 0000-0001-8532-313XUnclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2019-2020 · peak 2/yrCo-Author Collaboration Network
9 top collaborators · 24 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship3 papers
Recent·Most cited
- NeuroscienceProceedings of the National Academy of SciencesPeer-reviewed
The proteasome regulator PI31 is required for protein homeostasis, synapse maintenance and neuronal survival in mice
Adi Minis, Jose A. Rodriguez, Avi Levin…·Hermann Steller
This study shows that PI31 is essential for neuronal protein homeostasis, synapse maintenance, and survival in mice, with implications for neurodegenerative diseases.
42 citations - Cell BiologybioRxivPreprint
PI31 is an adaptor protein for proteasome transport in axons and required for synaptic development and function
Kai Liu, Sandra Jones, Adi Minis…·Hermann Steller
This study identifies PI31 as an adaptor protein linking proteasomes to dynein motors in axons, showing its role in synaptic development and function through regulated transport.
DOI 10.1101/364463