Manoj T. Duraisingh

This study creates a time-resolved multi-omics map of gene regulation in Toxoplasma gondii by integrating perturbation data with single-cell measurements, revealing regulatory networks and novel interactions.

The paper shows that isoleucine deficiency in human hemoglobin mirrors mosquito proteomes and limits malaria parasite growth.

This study reports cryo-EM ribosome structures and rRNA modifications in Babesia divergens, revealing novel modifications with potential therapeutic implications.

This study identifies a mutation in PfAQP and duplication of superoxide dismutase genes as mechanisms of resistance to cryptosporin in Plasmodium falciparum.

The paper identifies a conserved complex formed by PTRAMP, CSS, and Ripr in Plasmodium species that facilitates merozoite invasion of erythrocytes and shows its structural and functional conservation across species.

The paper maps transcriptional and chromatin changes during the Toxoplasma gondii lytic cycle, identifying AP2XII-8 as a key regulator of a ribosome regulon.

This paper identifies PhoD as a novel resistance determinant in Babesia species using comparative chemogenomics and validates its role through reverse genetics and functional perturbation.

The paper uses single-cell RNA sequencing to analyze three Babesia species, identifying conserved and species-specific gene expression patterns across the asexual replication cycle.

The paper uses bulk segregant analysis to identify genetic loci affecting malaria parasite growth in different media, finding EBA-140 as a key gene involved in media-dependent fitness.

The paper shows that Plasmodium falciparum strains use different invasion strategies based on red blood cell age and accessibility, revealing specialist and generalist behaviors affecting parasitemia.