SAP loss limits anti-insulin atypical B cell activation and pro-inflammatory CD8 T cells despite preserved Tfh responses to protect against type 1 diabetes
Landon M. Clark, Dudley H. McNitt, James McAninch…·Rachel H. Bonami
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Vanderbilt UniversityORCID 0000-0001-8592-4015Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Landon M. Clark, Dudley H. McNitt, James McAninch…·Rachel H. Bonami
Landon M. Clark, James McAninch, Dudley H. McNitt…·Rachel H. Bonami
This paper shows that BCL6 in T cells promotes type 1 diabetes by enabling anti-insulin B cells to become pathogenic, and that blocking BCL6 in T cells prevents diabetes even when insulin-reactive B cells are present.
Emily A. Henderson, Abby D. Ivey, Soo Jeon Choi…·Brian A. Boone
This study shows that intra-tumoral injection of Group A Streptococcus strains reduces pancreatic tumor growth by inhibiting neutrophil extracellular traps via the Scl1 protein.