Punn Augsornworawat

The paper shows that depolymerizing F-actin with latrunculin A during early differentiation improves hPSC-derived islet maturation and function by altering signaling pathways and lineage specification.

This study compares SC-β cells with fetal and adult β cells using single-cell sequencing, finding they share a core β-cell identity but have unique transcriptional profiles with neural-biased gene networks.

This study uses a patient-derived stem cell model to show that a specific WFS1 variant causes mild Wolfram syndrome, which can be treated with chemical chaperones.