ImmunologybioRxivPreprint
Lactate promotes IL-8 secretion in human alveolar macrophages through GPR132 and lipid metabolic reprogramming
DOI 10.64898/2026.01.27.701994
Author
Sally A. Clayton
University of BirminghamORCID 0000-0001-8609-9539Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2023-2026 · peak 1/yrCo-Author Collaboration Network
10 top collaborators · 21 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship3 papers
Recent·Most cited
- ImmunologybioRxivPreprint
Dexamethasone inhibits the LPS-induced activation of hypoxia-inducible factor 1 alpha (HIF-1α) in macrophages independently of the DUSP1-p38-TTP-HIF-1α regulatory axis.
Chloe Lockwood, Kalbinder K Daley, John D. O’Neil…·Andrew R. Clark
This study shows dexamethasone inhibits LPS-induced HIF-1α activation in macrophages through a glucocorticoid-sensitive mechanism, independent of the DUSP1-p38-TTP-HIF-1α pathway.
1 citation - ImmunologyDiscovery ImmunologyPeer-reviewed
The glucocorticoid dexamethasone inhibits HIF-1alpha stabilisation and metabolic reprogramming in lipopolysaccharide-stimulated primary macrophages.
Sally A. Clayton, Chloe Lockwood, John D. O’Neil…·Andrew R. Clark
This study shows dexamethasone inhibits HIF-1α stabilization and reduces GLUT1 expression in lipopolysaccharide-stimulated macrophages, impairing glucose uptake and metabolic reprogramming.