Author

Chloe Lockwood

University of BirminghamORCID 0009-0001-5100-4576Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Andrew R. ClarkiD· 2 shared John D. O’NeiliD· 2 shared Kalbinder K DaleyiD· 2 shared Sally A. ClaytoniD· 2 shared Daniel A. TennantiD· 1 shared Dina I. AbdelmottalebiD· 1 shared Katherine J HeighesiD· 1 shared Oliwia O BolimowskaiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 32 mutual co-author links

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2 shared papersImmunology

Andrew R. ClarkORCID

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Author profile →

2 papers

Recent·Most cited

ImmunologybioRxivPreprintSep 19, 2025

Dexamethasone inhibits the LPS-induced activation of hypoxia-inducible factor 1 alpha (HIF-1α) in macrophages independently of the DUSP1-p38-TTP-HIF-1α regulatory axis.

Chloe Lockwood, Kalbinder K Daley, John D. O’Neil…·Andrew R. Clark

This study shows dexamethasone inhibits LPS-induced HIF-1α activation in macrophages through a glucocorticoid-sensitive mechanism, independent of the DUSP1-p38-TTP-HIF-1α pathway.

1 citation

mouseexperimental assay

𝕏 PostBluesky

ImmunologyDiscovery ImmunologyPeer-reviewedJan 1, 2023

The glucocorticoid dexamethasone inhibits HIF-1alpha stabilisation and metabolic reprogramming in lipopolysaccharide-stimulated primary macrophages.

Sally A. Clayton, Chloe Lockwood, John D. O’Neil…·Andrew R. Clark

This study shows dexamethasone inhibits HIF-1α stabilization and reduces GLUT1 expression in lipopolysaccharide-stimulated macrophages, impairing glucose uptake and metabolic reprogramming.

23 citations

mousehuman

𝕏 PostBluesky