Mitchell A. Lazar

This paper identifies SLC25A34 as a key regulator of interorganellar lipid cycling, integrating circadian rhythms, diet, and temperature to control thermogenic metabolism.

This study shows that reduced hepatic phosphatidylcholine biosynthesis leads to copper deficiency, which promotes MASH through disrupted copper distribution and fibrogenesis.

This study identifies GH/IGF-1 signaling as a regulator of KHK expression, limiting fructose metabolism in the liver and contributing to MASLD.

The paper shows that hepatic vagal afferents transmit circadian signals between the liver and brain, influencing food intake and body weight.