Sebastian G. B. Furness

This paper introduces a pH-sensitive fluorescent probe, CalRexin:pHrodo Red, for detecting autophagy through high throughput imaging and validates its utility in screening autophagy modulators.

The paper shows that co-expression of G protein-coupled receptors can lead to emergent cellular behavior through a switch in downstream signaling, specifically demonstrating a reversal of dopamine D2 receptor activity.

This study compares two TrkB agonists, TDP6 and LM22A-4, in a mouse model of demyelination, finding that LM22A-4 promotes remyelination via indirect Trk receptor transactivation.