Author

Erik P. Hughes

University of UtahORCID 0000-0001-8672-3928Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Dean R TantiniD· 3 shared Abdelbasset A. FarahatiD· 1 shared Amber R. Syage· 1 shared Arabella YoungiD· 1 shared Asit Kumar MannaiD· 1 shared Benjamin T. SpikeiD· 1 shared Elnaz Mirzaei MehrabadiD· 1 shared Hosiana AbeweiD· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersImmunology

Dean R TantinORCID

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintOct 22, 2025

OCA-B/Pou2af1 Expression in T Cells Promotes PD-1 Blockade-Induced Autoimmunity but is Dispensable for Anti-Tumor Immunity

Junhong Du, Asit Kumar Manna, Miguel A. Medina-Serpas…·Dean R Tantin

This study shows OCA-B in T cells promotes ICI-induced autoimmunity but is not needed for anti-tumor immunity, suggesting it could be targeted to prevent autoimmunity without harming cancer treatments.

DOI 10.1101/2025.10.22.683978

mousebulk RNA-seq

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ImmunologyJournal of Clinical InvestigationPeer-reviewedApr 29, 2025

OCA-B promotes pathogenic maturation 1 of stem-like CD4+ T cells and autoimmune demyelination

Erik P. Hughes, Amber R. Syage, Elnaz Mirzaei Mehrabad…·Dean R Tantin

This study identifies OCA-B as a driver of pathogenic maturation in stem-like CD4+ T cells, promoting autoimmune demyelination in multiple sclerosis.

7 citations

mousebulk RNA-seq

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Developmental BiologybioRxivPreprintDec 1, 2020

Oct1 cooperates with Smad transcription factors to promote mesodermal lineage specification

Jelena Perovanović, Yifan Wu, Hosiana Abewe…·Dean R Tantin

This study shows that Oct1 works with Smad factors to activate mesodermal genes during differentiation, improving understanding of lineage specification.

1 citation

mousebulk RNA-seq

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