Benjamin T. Spike

This paper demonstrates that multiparametric QPI can assess drug sensitivity in patient-derived breast cancer models, including cryopreserved samples, revealing cellular heterogeneity and resistance mechanisms.

This study identifies OCA-B as a driver of pathogenic maturation in stem-like CD4+ T cells, promoting autoimmune demyelination in multiple sclerosis.

This study shows that Tenascin-C promotes early lung cancer progression by activating integrins and FAK in mouse models and human lung adenocarcinomas.

This study identifies CRIPTO's role in promoting extracellular vesicle uptake and fibroblast activation in TNBC, revealing a mechanism for tumor-stromal communication and potential therapeutic targets.

FIESTA imputes missing values in scRNA-seq data using non-negative matrix factorization, improving gene-cell-state relationships and marker discovery.