Rong Shen

This study determines the structure of the human vault cage with PARP4 and NAD+, revealing binding interfaces and NAD+ pockets, and shows proteomics differences in PARP4-depleted vaults.

This study uses cryo-EM to examine BK channel structures with locked voltage sensor states, revealing how voltage and calcium binding interact to control channel gating.

This study determines the cryo-EM structures of Prestin in multiple states, revealing its mechanism of area expansion and anion-binding site competition with salicylate.