Waruna Thotamune

This paper engineers blue-shifted melanopsin mutants using computational methods to enable subcellular optogenetic control without red light activation.

This paper introduces OptoIso, a photo-labile ligand that selectively activates βAR signaling at the cell surface or endomembranes using blue light, enabling precise study of its role in cardiac pathology.

This study introduces an optogenetic GDI tool to induce Gβγ signaling independently of GPCRs and demonstrates its ability to trigger macrophage migration.

This paper introduces an optogenetic tool to control GqGTP-PLCβ interactions and shows its role in regulating cell migration through competition with RhoGEFs.