Dhanushan Wijayaratna

This paper introduces novel GαGTP sensors to measure endogenous G protein signaling dynamics, revealing subtype-dependent dissociation and subcellular regulation.

This study identifies TTC7A's role in intestinal lumen formation by chaperoning PIK3C2A to generate PI(3,4)P2, with loss-of-function variants causing multiple lumens and rescue possible via exogenous PI(3,4)P2.

This paper engineers blue-shifted melanopsin mutants using computational methods to enable subcellular optogenetic control without red light activation.

This paper introduces an optogenetic tool to control GqGTP-PLCβ interactions and shows its role in regulating cell migration through competition with RhoGEFs.