Anoop Singh Chauhan

This study identifies USP50 as a ubiquitin-binding protein that regulates helicase and nuclease activities during DNA replication to prevent fork collapse and maintain genomic stability.

This study identifies Pin1-promoted SUMOylation of RNF168 as a mechanism to restrict its chromatin accumulation at DNA damage sites, linking it to cellular radioresistance.

This study identifies PIN1-mediated BRCA1 isomerisation as a regulator of replication fork protection through enhanced BRCA1-BARD1-RAD51 interaction, distinct from BRCA1's role in homologous recombination.