Alexander J. Garvin

This study identifies SUMO4 as a critical regulator of DNA double-strand break repair by promoting SUMO deconjugation through SENP1 and preventing excessive SUMOylation.

This study identifies USP50 as a ubiquitin-binding protein that regulates helicase and nuclease activities during DNA replication to prevent fork collapse and maintain genomic stability.

This study identifies Pin1-promoted SUMOylation of RNF168 as a mechanism to restrict its chromatin accumulation at DNA damage sites, linking it to cellular radioresistance.

The paper identifies RAD52 as the mediator of synthetic-lethal interactions between BRCA1/2, 53BP1 deficiencies, and DNA polymerase theta loss in murine cells.

The paper evaluates twenty-four anti-SUMO monoclonal antibodies for their sensitivity, specificity, and ability to detect different SUMO conjugation states across multiple assays.

This study shows that SAE2 deacetylation during mitosis biases SUMO2 over SUMO1 conjugation, affecting mitotic fidelity through SUMOylation of NuMA.

This paper identifies GSK3β-mediated phosphorylation of IRF1 at T181, which promotes its ubiquitination and degradation, essential for its transcriptional activity and anti-proliferative function.