Oscar Millet

This paper engineers conformational switches using nanobodies that fold upon ligand binding, enabling customizable receptors and sensors for biomarkers and drugs.

This study identifies a CHCH-helix interface between CHCHD10 and TDP-43CTD that modulates their assembly equilibria and aggregation behavior.

This study investigates how halophilic proteins achieve stability in high salt environments by analyzing the trade-off between electrostatic interactions and thermodynamic stability.

This study thermodynamically stabilizes human frataxin using computational methods, improving its stability and resistance to proteolysis without compromising function.