Francesca Peccati

This paper engineers conformational switches using nanobodies that fold upon ligand binding, enabling customizable receptors and sensors for biomarkers and drugs.

This study uses cryo-EM and molecular dynamics to explain glycoform preferences in prion strains RML and ME7, linking them to specific structural features of PrP.

This study identifies epistatic interactions in H3N2 influenza viruses that enable reversion to bind sialylated diLacNAc glycans, impacting receptor specificity and vaccine strain selection.

This paper synthesizes and characterizes UVI3502, a novel CB1 receptor antagonist/inverse agonist, showing high affinity for CB1 and low affinity for CB2, with potential interactions with GPR55.

This paper investigates how DarE enzyme modifies DarA to form ether and C-C crosslinks, identifying key residues and mechanisms involved in radical-mediated biosynthesis.

This study thermodynamically stabilizes human frataxin using computational methods, improving its stability and resistance to proteolysis without compromising function.