Alec Basil Heckert

This paper introduces Oblique Line Scan (OLS) illumination to enhance single-molecule tracking in living cells and solution, enabling high-throughput and sensitive protein dynamics measurements.

This study identifies a novel regulatory mechanism for WRN degradation via the PIAS4-RNF4-p97/VCP axis in MSI-H cancer cells using single molecule tracking and inhibitor screening.

The paper uses live cell imaging to show that RAR, not RXR, limits heterodimerization and chromatin binding of T2NRs, challenging previous assumptions about RXR's role.

The paper shows that RNA polymerase II depletion from the inactive X chromosome is due to reduced chromatin binding, not biophysical compartmentalization.

The paper shows that herpesvirus creates replication compartments that recruit RNA Polymerase II through DNA interactions, not phase separation, leading to local protein accumulations.