David Trombley McSwiggen

This paper introduces Oblique Line Scan (OLS) illumination to enhance single-molecule tracking in living cells and solution, enabling high-throughput and sensitive protein dynamics measurements.

The paper evaluates two cell-based assays for detecting drug-induced condensation of SARS-CoV-2 nucleocapsid protein, finding they provide complementary information to traditional high-content screens.

This study identifies a novel regulatory mechanism for WRN degradation via the PIAS4-RNF4-p97/VCP axis in MSI-H cancer cells using single molecule tracking and inhibitor screening.

The paper identifies eIF3 as a repressor of FTL mRNA translation and shows that SNPs causing hyperferritinemia disrupt this repression.

The paper shows that herpesvirus creates replication compartments that recruit RNA Polymerase II through DNA interactions, not phase separation, leading to local protein accumulations.

This study shows that RNA polymerase II CTDs undergo phase separation, forming clusters that are regulated by phosphorylation and CTD length.