Thomas G.W. Graham

The paper investigates spatial patterns of antimicrobial peptide expression in Drosophila larval fat body, finding that these patterns are predetermined and correlate with fluid flow.

This study shows that short activation domains, not just DNA-binding domains, significantly influence chromatin association of transcription factors in living cells.

This study uses PAPA-fSMT to investigate P-TEFb interactions and exchange in live cells, revealing dynamics of the 7SK ribonucleoprotein complex and its association with chromatin and BRD4.

The paper introduces a 25-camera multifocus microscope for high-speed 3D imaging and demonstrates its use in live imaging of organisms.

This study uses PAPA to show that IDRs of TFs mediate chromatin binding and interactions, challenging classical models of TF specificity.

The paper uses automated live-cell single-molecule tracking to study transcription factor dynamics in mouse enteroid monolayers, revealing contrasting diffusive behaviors that correlate with differentiation stages.

The paper uses live cell imaging to show that RAR, not RXR, limits heterodimerization and chromatin binding of T2NRs, challenging previous assumptions about RXR's role.

This study investigates how tuning low-complexity domain interactions in the oncogenic TF EWS/FLI1 affects transcription and oncogenic transformation in human cells.

This study shows that single-strand breaks cause replisome disassembly by generating different fork collapse structures depending on the strand, with CMG being passively removed during leading strand collapse and actively unloaded during lagging strand collapse.