Pyruvate kinase allostery resist hyperglycemia, obesity and inflammation by inducing TCA vortex and glucose U turn
Xuan Zhang, Xudong Jiang, Xiaobin Wu…·Qian Chen
This study shows that CLT-PKM interaction mimics ATP resistance by inducing a TCA vortex and glucose U turn, leading to weight loss and antioxidant effects against hyperglycemia, obesity, and inflammation.